Issue 9, 2011
From the journal:

Chemical Communications

A natural product-like inhibitor of NEDD8-activating enzyme†

Chung-Hang Leung,*a   Daniel Shiu-Hin Chan,b   Hui Yang,b   Ruben Abagyan,c   Simon Ming-Yuen Lee,d   Guo-Yuan Zhu,a   Wang-Fun Fonga  and  Dik-Lung Ma*b  

* Corresponding authors

a Centre for Cancer and Inflammation Research, School of Chinese Medicine, Hong Kong Baptist University, Kowloon Tong, Hong Kong
E-mail: duncanl@hkbu.edu.hk

b Department of Chemistry, Hong Kong Baptist University, Kowloon Tong, Hong Kong
E-mail: edmondma@hkbu.edu.hk

c Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, USA

d Institute of Chinese Medical Sciences, University of Macau, Av. Padre Tomás Pereira S.J., Taipa, Macao, China

Abstract

The natural product-like 6,6″-biapigenin has been identified as only the second inhibitor of NEDD8-activating enzyme using virtual screening. This compound was active in enzyme and cell-based assays, with potency in the micromolar range.

Graphical abstract: A natural product-like inhibitor of NEDD8-activating enzyme

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Article information

DOI
https://doi.org/10.1039/C0CC04927A
Article type
Communication
Submitted
12 Nov 2010
Accepted
15 Dec 2010
First published
14 Jan 2011

Chem. Commun., 2011,47, 2511-2513

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A natural product-like inhibitor of NEDD8-activating enzyme

C. Leung, D. S. Chan, H. Yang, R. Abagyan, S. M. Lee, G. Zhu, W. Fong and D. Ma, Chem. Commun., 2011, 47, 2511 DOI: 10.1039/C0CC04927A

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