Issue 6, 2011
From the journal:

Chemical Communications

Palladium-mediated site-selective Suzuki–Miyaura protein modification at genetically encoded aryl halides†

Christopher D. Spicera  and  Benjamin G. Davis*a  

* Corresponding authors

a Chemistry Research Laboratory, University of Oxford, 12 Mansfield Road, Oxford, UK
E-mail: Ben.Davis@chem.ox.ac.uk
Fax: +44 (0)1865 275674
Tel: +44 (0)1865 275652

Abstract

Site-specific genetic incorporation of unnatural p-halophenylalanine amino acid residues as ‘tags’ coupled with Pd(0)-mediated Suzuki–Miyuara ‘modification’ has been enabled by discovery of an effective small molecule palladium scavenger.

Graphical abstract: Palladium-mediated site-selective Suzuki–Miyaura protein modification at genetically encoded aryl halides

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Article information

DOI
https://doi.org/10.1039/C0CC04970K
Article type
Communication
Submitted
15 Nov 2010
Accepted
08 Dec 2010
First published
04 Jan 2011

Chem. Commun., 2011,47, 1698-1700

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Palladium-mediated site-selective Suzuki–Miyaura protein modification at genetically encoded aryl halides

C. D. Spicer and B. G. Davis, Chem. Commun., 2011, 47, 1698 DOI: 10.1039/C0CC04970K

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