Issue 9, 2011
From the journal:

Chemical Communications

Synthesis of oligonucleotides possessing versatile probes for PET labelling and their rapid ligand-free click reaction†

Takao Shiraishi,a   Yoshiaki Kitamura,b   Yoshihito Uenoab  and  Yukio Kitade*abc  

* Corresponding authors

a United Graduate School of Drug Discovery and Medical Information Sciences, Gifu University, Gifu, Japan
E-mail: ykkitade@gifu-u.ac.jp
Fax: +81 58 230 7632
Tel: +81 58 230 7630

b Department of Biomolecular Science, Faculty of Engineering, Gifu University, Japan

c Center for Advanced Drug Research, Gifu University, Japan

Abstract

We synthesised aryl acetylene derivatives as versatile probes for labelling of oligonucleotides. RNA oligomers bearing an aryl acetylene molecule rapidly reacted with benzylazide derivatives under ligand-free click reaction conditions.

Graphical abstract: Synthesis of oligonucleotides possessing versatile probes for PET labelling and their rapid ligand-free click reaction

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Article information

DOI
https://doi.org/10.1039/C0CC04979D
Article type
Communication
Submitted
16 Nov 2010
Accepted
09 Dec 2010
First published
12 Jan 2011

Chem. Commun., 2011,47, 2691-2693

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Synthesis of oligonucleotides possessing versatile probes for PET labelling and their rapid ligand-free click reaction

T. Shiraishi, Y. Kitamura, Y. Ueno and Y. Kitade, Chem. Commun., 2011, 47, 2691 DOI: 10.1039/C0CC04979D

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