Issue 16, 2011
From the journal:

Chemical Communications

c-di-GMP can form remarkably stable G-quadruplexes at physiological conditions in the presence of some planar intercalators†

Shizuka Nakayama,a   Ilana Kelsey,a   Jingxin Wanga  and  Herman O. Sintim*a  

* Corresponding authors

a Department of Chemistry and Biochemistry, University of Maryland, College Park, USA
E-mail: hsintim@umd.edu

Abstract

The ubiquitous bacterial biofilm regulator, c-di-GMP can form G-quadruplexes at physiological conditions in the presence of some aromatic compounds, such as acriflavine and proflavine. The fluorescence of these compounds is quenched upon c-di-GMP binding and some of the formed c-di-GMP G-quadruplexes are stable even at 75 °C.

Graphical abstract: c-di-GMP can form remarkably stable G-quadruplexes at physiological conditions in the presence of some planar intercalators

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Article information

DOI
https://doi.org/10.1039/C0CC05432A
Article type
Communication
Submitted
07 Dec 2010
Accepted
24 Feb 2011
First published
14 Mar 2011

Chem. Commun., 2011,47, 4766-4768

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c-di-GMP can form remarkably stable G-quadruplexes at physiological conditions in the presence of some planar intercalators

S. Nakayama, I. Kelsey, J. Wang and H. O. Sintim, Chem. Commun., 2011, 47, 4766 DOI: 10.1039/C0CC05432A

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