Issue 20, 2011
From the journal:

Chemical Communications

Enhanced translocation of poly(dt)45 through an α-hemolysin nanopore by binding with antibody†

Yi-Lun Ying,‡a   Da-Wei Li,‡a   Yang Li,a   Jeremy S. Leeb  and  Yi-Tao Long*a  

* Corresponding authors

a Shanghai Key Laboratory of Functional Materials Chemistry & Department of Chemistry, East China University of Science and Technology, 130 Meilong Road, Shanghai, P.R. China
E-mail: ytlong@ecust.edu.cn
Fax: +86-21-64250032

b Department of Biochemistry, University of Saskatchewan, Sask, Canada
E-mail: jeremy.lee@usask.ca

Abstract

The translocation time of poly(dT)45 through an α-hemolysin pore was reduced in the presence of a DNA-binding Fab fragment. The Fab acts as a rudder to steer the DNA into the pore.

Graphical abstract: Enhanced translocation of poly(dt)45 through an α-hemolysin nanopore by binding with antibody

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Article information

DOI
https://doi.org/10.1039/C0CC05787H
Article type
Communication
Submitted
25 Dec 2010
Accepted
25 Mar 2011
First published
14 Apr 2011

Chem. Commun., 2011,47, 5690-5692

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Enhanced translocation of poly(dt)45 through an α-hemolysin nanopore by binding with antibody

Y. Ying, D. Li, Y. Li, J. S. Lee and Y. Long, Chem. Commun., 2011, 47, 5690 DOI: 10.1039/C0CC05787H

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