Issue 13, 2011
From the journal:

Chemical Communications

Development of a quinoxaline-based fluorescent probe for quantitative estimation of protein binding site polarity†

Kentaro Kudo,a   Atsuya Momotake,a   Yoko Kanna,b   Yoshinobu Nishimuraa  and  Tatsuo Arai*a  

* Corresponding authors

a Graduate School of Pure and Applied Sciences, University of Tsukuba, Tsukuba, Ibaraki 305-8571, Japan
E-mail: arai@chem.tsukuba.ac.jp
Fax: +81 298-853-6503
Tel: +81 298-853-4315

b Faculty of Science, University of the Ryukyus, Nishihara, Okinawa 903-0213, Japan

Abstract

The compound 2-[(1E)-2-(1H-pyrrol-2-yl)ethenyl]-quinoxaline (PQX) is a promising fluorescent chromophore for the estimation of protein binding site polarity, due to its full-color solvatochromic fluorescence. A linear relationship was obtained between the peak emission wavenumber and ENT (normalized solvent polarity). The BSA binding site polarity was estimated from the solvatochromic plot.

Graphical abstract: Development of a quinoxaline-based fluorescent probe for quantitative estimation of protein binding site polarity

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Article information

DOI
https://doi.org/10.1039/C1CC10183H
Article type
Communication
Submitted
11 Jan 2011
Accepted
03 Feb 2011
First published
17 Feb 2011

Chem. Commun., 2011,47, 3867-3869

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Development of a quinoxaline-based fluorescent probe for quantitative estimation of protein binding site polarity

K. Kudo, A. Momotake, Y. Kanna, Y. Nishimura and T. Arai, Chem. Commun., 2011, 47, 3867 DOI: 10.1039/C1CC10183H

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