Fluorous ligand capture (FLC): a chemoselective solution-phase strategy for isolating 99mTc-labelled compounds in high effective specific activity

Justin W. Hicks; Laura E. Harrington; John F. Valliant

doi:10.1039/C1CC11079A

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Fluorous ligand capture (FLC): a chemoselective solution-phase strategy for isolating ^99mTc-labelled compounds in high effective specific activity†

Justin W. Hicks,^a Laura E. Harrington^a and John F. Valliant*^a

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* Corresponding authors

^a Departments of Chemistry and Chemical Biology & Medical Physics and Applied Radiation Sciences, McMaster University, Hamilton, ON, Canada
E-mail: valliant@mcmaster.ca
Fax: +905-522-7776
Tel: +905-525-9140 ext. 20182

Abstract

A new approach for preparing ^99mTc-labelled compounds in high effective specific activity was developed by utilizing a novel fluorous ligand capture (FLC) agent and a chemoselective filtration strategy. This paradigm eliminates the need to use HPLC to obtain technetium(I) based molecular imaging probes free from residual precursor.

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Article information

DOI: https://doi.org/10.1039/C1CC11079A
Article type: Communication
Submitted: 23 Feb 2011
Accepted: 04 May 2011
First published: 31 May 2011

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Chem. Commun., 2011,47, 7518-7520

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Fluorous ligand capture (FLC): a chemoselective solution-phase strategy for isolating ^99mTc-labelled compounds in high effective specific activity

J. W. Hicks, L. E. Harrington and J. F. Valliant, Chem. Commun., 2011, 47, 7518 DOI: 10.1039/C1CC11079A

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Chemical Communications