Fluorinated paramagnetic chelates as potential multi-chromic 19F tracer agents

Zhong-Xing Jiang; Yue Feng; Yihua Bruce Yu

doi:10.1039/C1CC11150G

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Fluorinated paramagnetic chelates as potential multi-chromic ¹⁹F tracer agents†

Zhong-Xing Jiang,^a Yue Feng^a and Yihua Bruce Yu*^ab

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* Corresponding authors

^a Department of Pharmaceutical Sciences, University of Maryland, Baltimore, MD 21201, USA
E-mail: byu@rx.umaryland.edu
Fax: +01 410-706-5017
Tel: +01 410-706-7514

^b Fischell Department of Bioengineering, University of Maryland, College Park, MD 20742, USA
Tel: +01 301-405-2829

Abstract

A class of potential multi-chromic ¹⁹F imaging tracers is made by pairing metal ions with a fluorinated chelator. All fluorinated metal chelates emit a single ¹⁹F signal. Paramagnetic metal ions shifted the ¹⁹F signal frequency and made the ¹⁹F relaxation rates insensitive toward local chemical environment.

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Article information

DOI: https://doi.org/10.1039/C1CC11150G
Article type: Communication
Submitted: 25 Feb 2011
Accepted: 28 Apr 2011
First published: 26 May 2011

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Chem. Commun., 2011,47, 7233-7235

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Fluorinated paramagnetic chelates as potential multi-chromic ¹⁹F tracer agents

Z. Jiang, Y. Feng and Y. B. Yu, Chem. Commun., 2011, 47, 7233 DOI: 10.1039/C1CC11150G

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