Issue 23, 2011
From the journal:

Chemical Communications

Arginine conjugates of metallo-supramolecular cylinders prescribe helicity and enhance DNA junction binding and cellular activity†‡

Lucia Cardo,a   Victoria Sadovnikova,a   Siriporn Phongtongpasuk,a   Nikolas J. Hodgesb  and  Michael J. Hannon*a  

* Corresponding authors

a School of Chemistry, University of Birmingham, Birmingham, UK
E-mail: m.j.hannon@bham.ac.uk
Fax: +44 121 414 7871
Tel: +44 121 414 2578

b School of Bioscience, University of Birmingham, Birmingham, UK

Abstract

The conjugation of arginine residues at the ends of a metallo-supramolecular triple-helical cylinder enables absolute control over the helicity of the cylinder core, and boosts the DNA junction recognition by the complexes and their activity against a cancer cell line.

Graphical abstract: Arginine conjugates of metallo-supramolecular cylinders prescribe helicity and enhance DNA junction binding and cellular activity

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Article information

DOI
https://doi.org/10.1039/C1CC11356A
Article type
Communication
Submitted
08 Mar 2011
Accepted
20 Apr 2011
First published
09 May 2011

Chem. Commun., 2011,47, 6575-6577

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Arginine conjugates of metallo-supramolecular cylinders prescribe helicity and enhance DNA junction binding and cellular activity

L. Cardo, V. Sadovnikova, S. Phongtongpasuk, N. J. Hodges and M. J. Hannon, Chem. Commun., 2011, 47, 6575 DOI: 10.1039/C1CC11356A

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