Issue 20, 2011
From the journal:

Chemical Communications

Fluorescent trimethyl-substituted naphthyridine as a ligand for C–C mismatch detection in CCG trinucleotide repeats†

Yusuke Sato,a   Atsuko Honjo,a   Daisuke Ishikawa,a   Seiichi Nishizawaa  and  Norio Teramae*a  

* Corresponding authors

a Department of Chemistry, Graduate School of Science, Tohoku University, Japan, Sendai 980-8578, Japan
E-mail: teramae@m.tohoku.ac.jp
Fax: +81-22-795-6552
Tel: +81-22-795-6549

Abstract

We report on the selective binding of 2-amino-5,6,7-trimethyl-1,8-naphthyridine (ATMND) to C–C mismatch present in the hairpin structures of (CCG)n trinucleotide repeats that are associated with neurological diseases; this binding is accompanied by significant fluorescence quenching of ATMND.

Graphical abstract: Fluorescent trimethyl-substituted naphthyridine as a ligand for C–C mismatch detection in CCG trinucleotide repeats

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Article information

DOI
https://doi.org/10.1039/C1CC11370D
Article type
Communication
Submitted
09 Mar 2011
Accepted
29 Mar 2011
First published
14 Apr 2011

Chem. Commun., 2011,47, 5885-5887

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Fluorescent trimethyl-substituted naphthyridine as a ligand for C–C mismatch detection in CCG trinucleotide repeats

Y. Sato, A. Honjo, D. Ishikawa, S. Nishizawa and N. Teramae, Chem. Commun., 2011, 47, 5885 DOI: 10.1039/C1CC11370D

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