We have investigated the homo-DNA templated Staudinger reduction of the profluorophore rhodamine azide and have applied this reaction to the detection of natural DNA with a hybrid homo-DNA/DNA molecular beacon. In this system the sensing and the reporting unit are bioorthogonal to each other which facilitates sequence design and increases fidelity.
M. Stoop and C. J. Leumann, Chem. Commun., 2011, 47, 7494 DOI: 10.1039/C1CC11469G
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