Issue 30, 2011
From the journal:

Chemical Communications

Chemical activation of MEK1 – a redox trigger for evaluating the effects of phosphorylation†

Toni L. Lamoureauxa  and  David H. Lee‡*a  

* Corresponding authors

a Department of Chemistry, Tufts University, Medford, USA
E-mail: david.h.lee@abbott.com
Fax: (617) 627-3443
Tel: (617) 627-3441

Abstract

An approach to generate mimics of phosphorylated serine proteins chemically through site-specific sulfonation of cysteine is presented. This chemical modification is reversible in the presence of reducing agent and therefore is analogous to the kinase/phosphatase system used in nature.

Graphical abstract: Chemical activation of MEK1 – a redox trigger for evaluating the effects of phosphorylation

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Article information

DOI
https://doi.org/10.1039/C1CC11745A
Article type
Communication
Submitted
27 Mar 2011
Accepted
20 Jun 2011
First published
30 Jun 2011

Chem. Commun., 2011,47, 8623-8625

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Chemical activation of MEK1 – a redox trigger for evaluating the effects of phosphorylation

T. L. Lamoureaux and D. H. Lee, Chem. Commun., 2011, 47, 8623 DOI: 10.1039/C1CC11745A

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