Issue 23, 2011
From the journal:

Chemical Communications

Generation of the CF3 radical from trifluoromethylsulfonium triflate and its trifluoromethylation of styrenes†

Cheng-Pan Zhang,a   Zong-Ling Wang,ab   Qing-Yun Chen,a   Chun-Tao Zhang,b   Yu-Cheng Guc  and  Ji-Chang Xiao*a  

* Corresponding authors

a Key Laboratory of Organofluorine Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 Lingling Road, Shanghai 200032, China
E-mail: jchxiao@mail.sioc.ac.cn
Fax: (+) 86-21-64166128

b Hunan University of Chinese Medicine, Changsha, Hunan Province 410208, China

c Syngenta, Jealott's Hill International Research Centre, Bracknell, Berkshire, UK

Abstract

The CF3 radical was generated from the reaction of S-(trifluoromethyl)diphenylsulfonium triflate with Na2S2O4 or HOCH2SO2Na under suitable conditions without further reduction. Based on this, a method for the synthesis of α-trifluoromethylated ketones has been successfully developed.

Graphical abstract: Generation of the CF3 radical from trifluoromethylsulfonium triflate and its trifluoromethylation of styrenes

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Article information

DOI
https://doi.org/10.1039/C1CC11765C
Article type
Communication
Submitted
28 Mar 2011
Accepted
14 Apr 2011
First published
11 May 2011

Chem. Commun., 2011,47, 6632-6634

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Generation of the CF3 radical from trifluoromethylsulfonium triflate and its trifluoromethylation of styrenes

C. Zhang, Z. Wang, Q. Chen, C. Zhang, Y. Gu and J. Xiao, Chem. Commun., 2011, 47, 6632 DOI: 10.1039/C1CC11765C

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