Issue 22, 2011
From the journal:

Chemical Communications

Triggered activity of a nicking endonuclease for mercuric(ii) ion-mediated duplex-like DNA cleavage†

Feng Li,ab   Yan Feng,b   Shufeng Liub  and  Bo Tang*a  

* Corresponding authors

a College of Chemistry, Chemical Engineering and Materials Science, Engineering Research Center of Pesticide and Medicine Intermediate Clean Production, Ministry of Education, Key Laboratory of Molecular and Nano Probes, Ministry of Education, Shandong Normal University, Jinan 250014, China
E-mail: tangb@sdnu.edu.cn
Fax: 86-531-86180017

b College of Chemistry and Molecular Engineering, Qingdao University of Science and Technology, Qingdao 266042, China

Abstract

The cleavage activity of a nicking endonuclease towards metal-ion-mediated duplex-like DNA can be triggered by the corresponding metal ions, which was demonstrated with mercuric(II) ion as a model via a simple electrochemical protocol.

Graphical abstract: Triggered activity of a nicking endonuclease for mercuric(ii) ion-mediated duplex-like DNA cleavage

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Article information

DOI
https://doi.org/10.1039/C1CC11858G
Article type
Communication
Submitted
01 Apr 2011
Accepted
20 Apr 2011
First published
06 May 2011

Chem. Commun., 2011,47, 6347-6349

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Triggered activity of a nicking endonuclease for mercuric(II) ion-mediated duplex-like DNA cleavage

F. Li, Y. Feng, S. Liu and B. Tang, Chem. Commun., 2011, 47, 6347 DOI: 10.1039/C1CC11858G

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