Issue 25, 2011
From the journal:

Chemical Communications

A novel catalytic process for trifluoromethylation of bromoaromatic compounds†

Bhupesh S. Samant*a  and  George W. Kabalkabc  

* Corresponding authors

a Division of Pharmaceutical Chemistry, Faculty of Pharmacy, Rhodes University, Grahamstown-6140, South Africa
E-mail: B.Samant@ru.ac.za
Fax: +27 466361205
Tel: +27 466038395

b University of Tennessee, Departments of Chemistry and Radiology, 1420 Circle Drive, Knoxville, USA

c UT Medical Hospital, Biomedical Imaging Center, Knoxville, USA

Abstract

The palladium-catalyzed trifluoromethylation of aryl bromides has been achieved in micellar media. The micellar conditions result in enhanced yields and are applicable to bromoaromatics with ketone, aldehyde, hydroxyl and amine functionalities.

Graphical abstract: A novel catalytic process for trifluoromethylation of bromoaromatic compounds

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Article information

DOI
https://doi.org/10.1039/C1CC12098K
Article type
Communication
Submitted
12 Apr 2011
Accepted
06 May 2011
First published
25 May 2011

Chem. Commun., 2011,47, 7236-7238

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A novel catalytic process for trifluoromethylation of bromoaromatic compounds

B. S. Samant and G. W. Kabalka, Chem. Commun., 2011, 47, 7236 DOI: 10.1039/C1CC12098K

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