Issue 26, 2011
From the journal:

Chemical Communications

From static to dynamic: escaping kinetic traps in hydrazone-based dynamic combinatorial libraries†

Sophie R. Beeren,a   Michael Pittelkow‡a  and  Jeremy K. M. Sanders*a  

* Corresponding authors

a University Chemical Laboratory, University of Cambridge, Lensfield Road, Cambridge CB2 1EW, United Kingdom
E-mail: jkms@cam.ac.uk
Fax: +44 1223 336017
Tel: +44 1223 336411

Abstract

Thermodynamic control over kinetically-trapped mixtures of hydrazone-based macrocycles is achieved by addition of an aromatic monohydrazide to generate dynamic combinatorial libraries (DCLs) of linear and macrocyclic oligomers.

Graphical abstract: From static to dynamic: escaping kinetic traps in hydrazone-based dynamic combinatorial libraries

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Article information

DOI
https://doi.org/10.1039/C1CC12268A
Article type
Communication
Submitted
19 Apr 2011
Accepted
18 May 2011
First published
03 Jun 2011

Chem. Commun., 2011,47, 7359-7361

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From static to dynamic: escaping kinetic traps in hydrazone-based dynamic combinatorial libraries

S. R. Beeren, M. Pittelkow and J. K. M. Sanders, Chem. Commun., 2011, 47, 7359 DOI: 10.1039/C1CC12268A

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