Issue 32, 2011
From the journal:

Chemical Communications

A new tool to assess ceramide bioactivity: 6-bromo-7-hydroxycoumarinyl-caged ceramide†

Young Ah Kim,a   Daniel M. Carter Ramirez,bc   Willard J. Costain,d   Linda J. Johnstonb  and  Robert Bittman*a  

* Corresponding authors

a Department of Chemistry and Biochemistry, Queens College of The City University of New York, Flushing, USA
E-mail: robert.bittman@qc.cuny.edu
Tel: +1 718-997-3279

b Steacie Institute for Molecular Sciences, National Research Council of Canada, Ottawa, Canada

c Department of Chemistry, University of Ottawa, Ottawa, Canada

d Institute for Biological Sciences, National Research Council of Canada, Ottawa, Canada

Abstract

The bioactivity of natural, long-chain ceramides has until now been studied after its delivery to cells in organic solvent mixtures containing dodecane. We have synthesized ceramides conjugated to a (6-bromo-7-hydroxycoumarin-4-yl)methyl group. The photocaged ceramide is efficiently released with 350 nm light in aqueous solution at neutral pH, thus providing a promising new tool to study ceramide's properties.

Graphical abstract: A new tool to assess ceramide bioactivity: 6-bromo-7-hydroxycoumarinyl-caged ceramide

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Article information

DOI
https://doi.org/10.1039/C1CC12345A
Article type
Communication
Submitted
21 Apr 2011
Accepted
29 Jun 2011
First published
15 Jul 2011

Chem. Commun., 2011,47, 9236-9238

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A new tool to assess ceramide bioactivity: 6-bromo-7-hydroxycoumarinyl-caged ceramide

Y. A. Kim, D. M. C. Ramirez, W. J. Costain, L. J. Johnston and R. Bittman, Chem. Commun., 2011, 47, 9236 DOI: 10.1039/C1CC12345A

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