Issue 33, 2011

Synthesis of epoxybenzo[d]isothiazole 1,1-dioxides via a reductive-Heck, metathesis-sequestration protocol

Abstract

An atom-economical purification protocol, using solution phase processing viaring-opening metathesis polymerization (ROMP) has been developed for the synthesis of tricyclic sultams. This chromatography-free method allows for convenient isolation of reductive-Heck products and reclamation of excess starting material via sequestration involving metathesis catalysts and a catalyst-armed Si-surface.

Graphical abstract: Synthesis of epoxybenzo[d]isothiazole 1,1-dioxides via a reductive-Heck, metathesis-sequestration protocol

Supplementary files

Article information

Article type
Communication
Submitted
28 Apr 2011
Accepted
25 May 2011
First published
05 Jul 2011

Chem. Commun., 2011,47, 9528-9530

Synthesis of epoxybenzo[d]isothiazole 1,1-dioxides via a reductive-Heck, metathesis-sequestration protocol

N. Asad, P. R. Hanson, T. R. Long, D. K. Rayabarapu and A. Rolfe, Chem. Commun., 2011, 47, 9528 DOI: 10.1039/C1CC12503F

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