Issue 28, 2011
From the journal:

Chemical Communications

Drug release from hydrazone-containing peptide amphiphiles†

John B. Matsona  and  Samuel I. Stupp*abcd  

* Corresponding authors

a Institute for BioNanotechnology in Medicine, Northwestern University, Chicago, USA
E-mail: s-stupp@northwestern.edu
Fax: (+312) 503-2482
Tel: (+312) 503-6713

b Department of Chemistry, Northwestern University, Evanston, USA

c Department of Materials Science and Engineering, Northwestern University, Evanston, USA

d Feinberg School of Medicine, Northwestern University, Chicago, USA

Abstract

Hydrolytically-labile hydrazones in peptide amphiphiles were studied as degradable tethers for release of the drug nabumetone from nanofiber gels. On-resin addition of the novel compound tri-Boc-hydrazido adipic acid to a lysine ε-amine allowed for precise placement of a hydrazide in a peptide sequence.

Graphical abstract: Drug release from hydrazone-containing peptide amphiphiles

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Article information

DOI
https://doi.org/10.1039/C1CC12570B
Article type
Communication
Submitted
02 May 2011
Accepted
27 May 2011
First published
15 Jun 2011

Chem. Commun., 2011,47, 7962-7964

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Drug release from hydrazone-containing peptide amphiphiles

J. B. Matson and S. I. Stupp, Chem. Commun., 2011, 47, 7962 DOI: 10.1039/C1CC12570B

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