Stable aluminium fluoride chelates with triazacyclononane derivatives proved by X-ray crystallography and 18F-labeling study

Dinesh Shetty; Soo Young Choi; Jae Min Jeong; Ji Youn Lee; Lathika Hoigebazar; Yun-Sang Lee; Dong Soo Lee; June-Key Chung; Myung Chul Lee; Young Keun Chung

doi:10.1039/C1CC13151F

Stable aluminium fluoride chelates with triazacyclononane derivatives proved by X-ray crystallography and ¹⁸F-labeling study†

Dinesh Shetty,^ab Soo Young Choi,^c Jae Min Jeong,*^ab Ji Youn Lee,^ab Lathika Hoigebazar,^ab Yun-Sang Lee,^ab Dong Soo Lee,^a June-Key Chung,^ab Myung Chul Lee^a and Young Keun Chung^c

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* Corresponding authors

^a Department of Nuclear Medicine, Department of Radiation Applied Life Science and Institute of Radiation Medicine, Seoul National University College of Medicine, Seoul, Korea
E-mail: jmjng@snu.ac.kr

^b Clinical Research Institute and Cancer Research Institute, Seoul National University Hospital, Seoul, Korea

^c Intelligent Textile System Research Center and Department of Chemistry, Seoul National University, Seoul, Korea

Abstract

A single crystal structure of an aluminium-fluoride complex of a model compound (NODA-benzyl) was studied to understand the co-ordination chemistry. Series of ligands with an extra carboxylic acid linker for biomolecule conjugation were studied for improved ¹⁸F-labeling applications.

Chemical Communications

Stable aluminium fluoride chelates with triazacyclononane derivatives proved by X-ray crystallography and ¹⁸F-labeling study†

Abstract

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Stable aluminium fluoride chelates with triazacyclononane derivatives proved by X-ray crystallography and ¹⁸F-labeling study

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