Issue 39, 2011
From the journal:

Chemical Communications

A general synthesis of dirhodium metallopeptides as MDM2 ligands†

Alexander N. Zaykova  and  Zachary T. Ball*a  

* Corresponding authors

a Department of Chemistry, Rice University, 6100 Main St., MS60, Houston, TX, USA
E-mail: zb1@rice.edu

Abstract

A synthesis of multifunctional dirhodium metallopeptide ligands for MDM2 is presented. An orthogonal protection scheme of palladium-catalyzed de-allylation on a metallopeptide substrate allows specific dirhodium incorporation in a complex peptide. Sequence effects on MDM2 binding are discussed.

Graphical abstract: A general synthesis of dirhodium metallopeptides as MDM2 ligands

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Article information

DOI
https://doi.org/10.1039/C1CC13169A
Article type
Communication
Submitted
29 May 2011
Accepted
23 Aug 2011
First published
12 Sep 2011

Chem. Commun., 2011,47, 10927-10929

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A general synthesis of dirhodium metallopeptides as MDM2 ligands

A. N. Zaykov and Z. T. Ball, Chem. Commun., 2011, 47, 10927 DOI: 10.1039/C1CC13169A

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