Issue 35, 2011
From the journal:

Chemical Communications

Synthesis of a MUC1-glycopeptide–BSA conjugate vaccine bearing the 3′-deoxy-3′-fluoro-Thomsen–Friedenreich antigen†‡

Anja Hoffmann-Röder*a  and  Manuel Johannes§a  

* Corresponding authors

a Institut für Organische Chemie, Johannes Gutenberg-Universität Mainz, Duesbergweg 10-14, D-55128 Mainz, Germany
E-mail: hroeder@uni-mainz.de
Fax: +49 6231 3926066
Tel: +49 6131 3922417

Abstract

A novel MUC1-glycopeptide–BSA conjugate vaccine with a specifically fluorinated Thomsen–Friedenreich antigen side chain at Thr6 was prepared. Preliminary immunological experiments reveal specific binding of the tumor-associated glycopeptide antigen analog by anti-MUC1-mouse antibodies.

Graphical abstract: Synthesis of a MUC1-glycopeptide–BSA conjugate vaccine bearing the 3′-deoxy-3′-fluoro-Thomsen–Friedenreich antigen

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Article information

DOI
https://doi.org/10.1039/C1CC13184B
Article type
Communication
Submitted
30 May 2011
Accepted
19 Jul 2011
First published
04 Aug 2011

Chem. Commun., 2011,47, 9903-9905

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Synthesis of a MUC1-glycopeptide–BSA conjugate vaccine bearing the 3′-deoxy-3′-fluoro-Thomsen–Friedenreich antigen

A. Hoffmann-Röder and M. Johannes, Chem. Commun., 2011, 47, 9903 DOI: 10.1039/C1CC13184B

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