Issue 36, 2011
From the journal:

Chemical Communications

Characterization and application of the Fe(ii) and α-ketoglutarate dependent hydroxylase FrbJ†

Matthew A. DeSieno,ac   Wilfred A. van der Donkbc  and  Huimin Zhao*abcd  

* Corresponding authors

a Department of Chemical and Biomolecular Engineering, University of Illinois at Urbana-Champaign, 600 S. Mathews Avenue, Urbana, USA
E-mail: zhao5@illinois.edu
Fax: +1-217-333-5052
Tel: +1-217-333-2631

b Departments of Chemistry and Biochemistry, University of Illinois at Urbana-Champaign, 600 S. Mathews Avenue, Urbana, USA

c Institute for Genomic Biology, University of Illinois at Urbana-Champaign, 600 S. Mathews Avenue, Urbana, USA

d Department of Bioengineering, Center for Biophysics and Computational Biology, University of Illinois at Urbana-Champaign, 600 S. Mathews Avenue, Urbana, USA

Abstract

The Fe(II) and α-ketoglutarate-dependent hydroxylase FrbJ was previously demonstrated to utilize FR-900098 synthesizing a second phosphonate FR-33289. Here we assessed its ability to hydroxylate other possible substrates, generating a library of potential antimalarial compounds. Through a series of bioassays and in vitro experiments, we identified two new antimalarials.

Graphical abstract: Characterization and application of the Fe(ii) and α-ketoglutarate dependent hydroxylase FrbJ

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Article information

DOI
https://doi.org/10.1039/C1CC13597J
Article type
Communication
Submitted
16 Jun 2011
Accepted
22 Jul 2011
First published
10 Aug 2011

Chem. Commun., 2011,47, 10025-10027

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Characterization and application of the Fe(II) and α-ketoglutarate dependent hydroxylase FrbJ

M. A. DeSieno, W. A. van der Donk and H. Zhao, Chem. Commun., 2011, 47, 10025 DOI: 10.1039/C1CC13597J

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