Non-hemolytic α-AApeptides as antimicrobial peptidomimetics

Shruti Padhee; Yaogang Hu; Youhong Niu; Ge Bai; Haifan Wu; Frankie Costanza; Leigh West; Lacey Harrington; Lindsey N. Shaw; Chuanhai Cao; Jianfeng Cai

doi:10.1039/C1CC13684D

Non-hemolytic α-AApeptides as antimicrobial peptidomimetics†

Shruti Padhee,^a Yaogang Hu,^a Youhong Niu,^a Ge Bai,^a Haifan Wu,^a Frankie Costanza,^a Leigh West,^b Lacey Harrington,^c Lindsey N. Shaw,^c Chuanhai Cao^d and Jianfeng Cai*^a

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^a Department of Chemistry, University of South Florida, 4202 E. Fowler Ave, Tampa, USA
E-mail: jianfengcai@usf.edu
Fax: +1-813-974-3203
Tel: +1-813-974-9506

^b Florida Center of Excellence for Drug Discovery and Innovation, University of South Florida, 3720 Spectrum Blvd, Tampa, FL, USA

^c Department of Cell Biology, Microbiology and Molecular Biology, 4202 E. Fowler Ave, Tampa, USA

^d Dept. of Molecular Pharmacology and Physiology, 4001 E. Fletcher Ave., Tampa, USA

Abstract

We report a new class of peptide mimetics, α-AApeptides, that display broad-spectrum activity against both Gram-negative and Gram-positive bacteria and fungi. With non-hemolytic activity, resistance to protease hydrolysis, and easy sequence programmability, α-AApeptides may emerge as a novel class of antibiotics.

Chemical Communications

Non-hemolytic α-AApeptides as antimicrobial peptidomimetics†

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Non-hemolytic α-AApeptides as antimicrobial peptidomimetics

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