Issue 37, 2011
From the journal:

Chemical Communications

Yb(OTf)3 catalyzed new cascade reaction: a facile assembly of fused quinazolinones†

K. Siva Kumar,ab   P. Mahesh Kumar,a   M. Appi Reddy,a   Md. Ferozuddin,a   M. Sreenivasulu,a   Ahamed A. Jafar,b   G. R. Krishna,c   C. Malla Reddy,c   D. Rambabu,d   K. Shiva Kumar,d   Sarbani Pale  and  Manojit Pal*d  

* Corresponding authors

a Custom Pharmaceutical Services, Dr Reddy's Laboratories Limited, Bollaram Road Miyapur, Hyderabad 500 049, India

b PG and Research Department of Chemistry, Jamal Mohamed College, Tiruchirappalli 620020, Tamil Nadu, India

c Department of Chemical Sciences, Indian Institute of Science Education and Research, Kolkata, West Bengal, India

d Institute of Life Sciences, University of Hyderabad Campus, Gachibowli, Hyderabad 500 046, India
E-mail: manojitpal@rediffmail.com

e Department of Chemistry, MNR Degree and PG College, Kukatpally, Hyderabad, India

Abstract

A one-pot Yb(III)-mediated cascade reaction has been developed leading to small molecules based on a novel structural motif, i.e.quinazolin-4-one moiety fused with an isoquinoline ring, for potential inhibition of TNF-α.

Graphical abstract: Yb(OTf)3 catalyzed new cascade reaction: a facile assembly of fused quinazolinones

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Article information

DOI
https://doi.org/10.1039/C1CC13695J
Article type
Communication
Submitted
21 Jun 2011
Accepted
01 Aug 2011
First published
19 Aug 2011

Chem. Commun., 2011,47, 10263-10265

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Yb(OTf)3 catalyzed new cascade reaction: a facile assembly of fused quinazolinones

K. S. Kumar, P. M. Kumar, M. A. Reddy, Md. Ferozuddin, M. Sreenivasulu, A. A. Jafar, G. R. Krishna, C. M. Reddy, D. Rambabu, K. Shiva Kumar, S. Pal and M. Pal, Chem. Commun., 2011, 47, 10263 DOI: 10.1039/C1CC13695J

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