A novel pH-sensitive (±)-α-tocopherol–5-fluorouracil adduct with antioxidant and anticancer properties

Dong-Wei Li; Fang-Fang Tian; Yu-Shu Ge; Xin-Liang Ding; Jia-Han Li; Zi-Qiang Xu; Mei-Fang Zhang; Xiao-Le Han; Ran Li; Feng-Lei Jiang; Yi Liu

doi:10.1039/C1CC13821A

A novel pH-sensitive (±)-α-tocopherol–5-fluorouracil adduct with antioxidant and anticancer properties†

Dong-Wei Li,^a Fang-Fang Tian,^a Yu-Shu Ge,^a Xin-Liang Ding,^a Jia-Han Li,^a Zi-Qiang Xu,^a Mei-Fang Zhang,^a Xiao-Le Han,^a Ran Li,^a Feng-Lei Jiang^a and Yi Liu*^ab

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^a State Key Laboratory of Virology & Key Laboratory of Analytical Chemistry for Biology and Medicine (MOE), College of Chemistry and Molecular Sciences, Wuhan University, Wuhan 430072, P. R. China
E-mail: yiliuchem@whu.edu.cn
Fax: +86-27-6854067
Tel: +86-27-68756667

^b Department of Chemistry and Life Sciences, Xianning University, Xianning 437005, P. R. China

Abstract

A novel pH-sensitive (±)-α-tocopherol–5-fluorouracil (VE-5-FU) adduct with antioxidant and anticancer properties for antioxidant-based cancer chemoprevention was synthesized and utilized for selective drug release in the stomach.

Chemical Communications

A novel pH-sensitive (±)-α-tocopherol–5-fluorouracil adduct with antioxidant and anticancer properties†

Abstract

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A novel pH-sensitive (±)-α-tocopherol–5-fluorouracil adduct with antioxidant and anticancer properties

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