Issue 44, 2011
From the journal:

Chemical Communications

Asymmetric reduction of ketones with recombinant E. coli whole cells in neat substrates

Andre Jakoblinnert,a   Radoslav Mladenov,a   Albert Paul,a   Fabrizio Sibilla,a   Ulrich Schwaneberg,a   Marion B. Ansorge-Schumacher*b  and  Pablo Domínguez de María*c  

* Corresponding authors

a Lehrstuhl für Biotechnology, RWTH Aachen University, Worringer Weg 1, D-52074 Aachen, Germany

b Institute of Chemistry, Department of Enzyme Technology (TC4), Technische Universität Berlin, Straße des 17. Juni 124, D-10623 Berlin, Germany
E-mail: m.ansorge@chem.tu-berlin.de
Fax: +49 30 314 22261
Tel: +49 30 314 22127

c Institut für Technische und Makromolekulare Chemie (ITMC), RWTH Aachen University, Worringer Weg 1, D-52074 Aachen, Germany
E-mail: Dominguez@itmc.rwth-aachen.de
Fax: +49 241 8022177
Tel: +49 241 8020468

Abstract

The asymmetric reduction of ketones is performed by using lyophilized whole cells in neat substrates with defined water activity (aw). Ketones and alcohols prone to be unstable in aqueous media can now be converted via biocatalysis.

Graphical abstract: Asymmetric reduction of ketones with recombinant E. coli whole cells in neat substrates

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Article information

DOI
https://doi.org/10.1039/C1CC14097C
Article type
Communication
Submitted
08 Jul 2011
Accepted
05 Oct 2011
First published
17 Oct 2011

Chem. Commun., 2011,47, 12230-12232

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Asymmetric reduction of ketones with recombinant E. coli whole cells in neat substrates

A. Jakoblinnert, R. Mladenov, A. Paul, F. Sibilla, U. Schwaneberg, M. B. Ansorge-Schumacher and P. D. de María, Chem. Commun., 2011, 47, 12230 DOI: 10.1039/C1CC14097C

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