Issue 39, 2011
From the journal:

Chemical Communications

A self-immobilizing and fluorogenic unnatural amino acid that mimics phosphotyrosine†

Jingyan Ge,a   Lin Lia  and  Shao Q. Yao*a  

* Corresponding authors

a Department of Chemistry, National University of Singapore, 3 Science Drive 3, Singapore 117543, Singapore
E-mail: chmyaosq@nus.edu.sg
Fax: +65 67791691
Tel: +65 65162925

Abstract

Synthesis of the first self-immobilizing, fluorogenic unnatural amino acid that mimics phosphotyrosine (pTyr) is reported. By using solid-phase peptide synthesis, it was subsequently incorporated into peptide-based probes which found applications in bioimaging and fluorescence-activated cell sorting (FACS).

Graphical abstract: A self-immobilizing and fluorogenic unnatural amino acid that mimics phosphotyrosine

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Article information

DOI
https://doi.org/10.1039/C1CC14653J
Article type
Communication
Submitted
29 Jul 2011
Accepted
31 Aug 2011
First published
12 Sep 2011

Chem. Commun., 2011,47, 10939-10941

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A self-immobilizing and fluorogenic unnatural amino acid that mimics phosphotyrosine

J. Ge, L. Li and S. Q. Yao, Chem. Commun., 2011, 47, 10939 DOI: 10.1039/C1CC14653J

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