Issue 43, 2011
From the journal:

Chemical Communications

C-Reactive protein-directed immobilization of phosphocholineligands on a solid surface†

Eunjoo Kim,a   Hyun-Chul Kim,a   Se Geun Lee,a   Sung Jun Lee,a   Tae-Jung Go,a   Chul Su Baeka  and  Sang Won Jeong*a  

* Corresponding authors

a Nano & Bio Research Division, Daegu Gyeongbuk Institute of Science and Technology (DGIST), Daegu 711-873, Korea
E-mail: sjeong@dgist.ac.kr
Fax: +82-53-785-3559
Tel: +82-53-785-2510

Abstract

The complexes of C-reactive protein (CRP) with its polymerizable phosphocholine ligands adsorbed at the styrene–water interface were polymerized. The molecularly imprinted polymer (MIP) exhibited a binding affinity for CRP comparable to that of immobilized anti-CRP antibody. The determination of human serum CRP using the MIP-based sandwich immunoassay has been demonstrated.

Graphical abstract: C-Reactive protein-directed immobilization of phosphocholine ligands on a solid surface

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Article information

DOI
https://doi.org/10.1039/C1CC15079K
Article type
Communication
Submitted
16 Aug 2011
Accepted
27 Sep 2011
First published
06 Oct 2011

Chem. Commun., 2011,47, 11900-11902

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C-Reactive protein-directed immobilization of phosphocholine ligands on a solid surface

E. Kim, H. Kim, S. G. Lee, S. J. Lee, T. Go, C. S. Baek and S. W. Jeong, Chem. Commun., 2011, 47, 11900 DOI: 10.1039/C1CC15079K

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