Issue 46, 2011
From the journal:

Chemical Communications

Silvermetallation of hen egg white lysozyme: X-ray crystal structure and NMR studies†

Matthew J. Panzner,a   Stephanie M. Bilinovich,a   Wiley J. Youngsa  and  Thomas C. Leeper*a  

* Corresponding authors

a Center for Silver Therapeutics Research, Department of Chemistry, The University of Akron, Akron, USA
E-mail: tleeper@uakron.edu

Abstract

The X-ray crystal structure, NMR binding studies, and enzyme activity of silver(I) metallated hen egg white lysozyme are presented. Primary bonding of silver is observed through His15 with secondary bonding interactions coming from nearby Arg14 and Asp87. A covalently bound nitrate completes a four coordinate binding pocket.

Graphical abstract: Silver metallation of hen egg white lysozyme: X-ray crystal structure and NMR studies

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Article information

DOI
https://doi.org/10.1039/C1CC15908A
Article type
Communication
Submitted
22 Sep 2011
Accepted
18 Oct 2011
First published
31 Oct 2011

Chem. Commun., 2011,47, 12479-12481

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Silver metallation of hen egg white lysozyme: X-ray crystal structure and NMR studies

M. J. Panzner, S. M. Bilinovich, W. J. Youngs and T. C. Leeper, Chem. Commun., 2011, 47, 12479 DOI: 10.1039/C1CC15908A

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