Diastereotopos-differentiating C–H activation reactions at methylene groups

Abstract

The activation of C–H bonds has become a widely used method which allows for the direct transformation of C–H bonds into synthetically more valuable C–C and C–X bonds in a selective manner. This critical review aims to summarize and to highlight a specific subgroup of these transformations, C–H activation reactions of chiral substrates bearing diastereotopic hydrogen atoms at methylene groups (95 references).