Issue 5, 2011
From the journal:

Chemical Society Reviews

The frequently overlooked importance of solvent in free radical syntheses

Grzegorz Litwinienko,a   A. L. J. Beckwithb  and  K. U. Ingold*c  

* Corresponding authors

a Faculty of Chemistry, University of Warsaw, Pasteura 1, 02-093 Warsaw, Poland
E-mail: litwin@chem.uw.edu.pl
Fax: +48 22 8222380
Tel: +48 22 8220211 ext. 333

b (Late) Professor at the Research School of Chemistry, Australian National University, Canberra, ACT, Australia

c National Research Council, Ottawa, Canada
E-mail: Keith.Ingold@nrc-cnrc.gc.ca
Fax: +1 613 990 0709
Tel: +1 613 990 0938

Abstract

This tutorial review is designed to dispel the myth, still believed by many synthetic organic chemists, that radical-based syntheses are free from significant solvent effects. However, many synthetically valuable radical reactions do exhibit large kinetic solvent effects. It is therefore important to select the solvent for any proposed radical synthesis with considerable care if good product yields are to be achieved.

Graphical abstract: The frequently overlooked importance of solvent in free radical syntheses

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Article information

DOI
https://doi.org/10.1039/C1CS15007C
Article type
Tutorial Review
Submitted
08 Jan 2011
First published
22 Feb 2011

Chem. Soc. Rev., 2011,40, 2157-2163

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The frequently overlooked importance of solvent in free radical syntheses

G. Litwinienko, A. L. J. Beckwith and K. U. Ingold, Chem. Soc. Rev., 2011, 40, 2157 DOI: 10.1039/C1CS15007C

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