Issue 2, 2011

Synthesis of substituted 8-aminoquinolines and phenanthrolines through a Povarov approach

Abstract

The synthesis of 8-aminoquinolines and 1,10-phenanthrolines with substituents in α of the nitrogen has been performed through an inverse-demanding aza-Diels–Alder (Povarov reaction) in the fluoroalcohols TFE or HFIP. This path involves simple starting materials: 1,2-phenylenediamines, enol ethers and aldehydes.

Graphical abstract: Synthesis of substituted 8-aminoquinolines and phenanthrolines through a Povarov approach

Supplementary files

Article information

Article type
Communication
Submitted
27 Jul 2010
Accepted
23 Sep 2010
First published
18 Oct 2010

Org. Biomol. Chem., 2011,9, 347-350

Synthesis of substituted 8-aminoquinolines and phenanthrolines through a Povarov approach

K. De, J. Legros, B. Crousse, S. Chandrasekaran and D. Bonnet-Delpon, Org. Biomol. Chem., 2011, 9, 347 DOI: 10.1039/C0OB00496K

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