Issue 2, 2011

Wilsoniamines A and B: novel alkaloids from the temperate Australian bryozoan, Amathia wilsoni

Abstract

Two novel alkaloids, wilsoniamines A and B, both possessing a hexahydropyrrolo[1,2-c]imidazol-1-one ring system that has not previously been found in nature, together with a new alkaloid, amathamide H and a known alkaloid, amathamide C were isolated from the temperate Australian bryozoan, Amathia wilsoni. MS and NMR analysis established the structure of the new compounds and indicated that the structure of amathamide C and several related compounds be revised. Amathamides C and H showed moderate anti-malarial and anti-trypanosomal activity.

Graphical abstract: Wilsoniamines A and B: novel alkaloids from the temperate Australian bryozoan, Amathia wilsoni

Supplementary files

Article information

Article type
Paper
Submitted
04 Aug 2010
Accepted
23 Sep 2010
First published
24 Sep 2010

Org. Biomol. Chem., 2011,9, 604-609

Wilsoniamines A and B: novel alkaloids from the temperate Australian bryozoan, Amathia wilsoni

A. R. Carroll, S. Duffy, M. Sykes and V. M. Avery, Org. Biomol. Chem., 2011, 9, 604 DOI: 10.1039/C0OB00538J

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