Issue 5, 2011
From the journal:

Organic & Biomolecular Chemistry

A facile process for the asymmetric synthesis of β-trifluoromethylated β-amino ketonesvia addition of ketone enolates to sulfinylimine†‡

Haibo Mei,a   Yiwen Xiong,a   Jianlin Han*a  and  Yi Pan*ab  

* Corresponding authors

a School of Chemistry and Chemical Engineering, Nanjing University, Nanjing, China
E-mail: hanjl@nju.edu.cn
Fax: +86-25-83592846
Tel: +86-25-83593153

b State of Key Laboratory of Coordination, Nanjing University, Nanjing, China
E-mail: yipan@nju.edu.cn

Abstract

An efficient method for the asymmetric synthesis of β-trifluoromethylated β-amino ketonesvia addition of ketone-derivative enolates to trifluoromethylated sulfinylimine has been developed, with good chemical yields and excellent diastereoselectivities. This practical method was also proved to be suitable for large-scale preparation.

Graphical abstract: A facile process for the asymmetric synthesis of β-trifluoromethylated β-amino ketonesvia addition of ketone enolates to sulfinylimine

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Article information

DOI
https://doi.org/10.1039/C0OB00586J
Article type
Paper
Submitted
16 Aug 2010
Accepted
11 Nov 2010
First published
05 Jan 2011

Org. Biomol. Chem., 2011,9, 1402-1406

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A facile process for the asymmetric synthesis of β-trifluoromethylated β-amino ketonesvia addition of ketone enolates to sulfinylimine

H. Mei, Y. Xiong, J. Han and Y. Pan, Org. Biomol. Chem., 2011, 9, 1402 DOI: 10.1039/C0OB00586J

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