Issue 3, 2011
From the journal:

Organic & Biomolecular Chemistry

Stereoselective palladium-catalyzed allylic alkylations of peptideamide enolates†

Swarup Dattaa  and  Uli Kazmaier*a  

* Corresponding authors

a Institut für Organische Chemie, Universität des Saarlandes, Saarbrücken, Germany
E-mail: u.kazmaier@mx.uni-saarland.de
Fax: +49 681 302 2409
Tel: +49 681 302 3409

Abstract

Pd-catalyzed allylations are an excellent tool for stereoselective peptide modifications, being clearly superior to normal alkylations. The reactions proceed not only in high yield, but also high regio- and diastereoselectivities, and trans-products are formed exclusively. Therefore, this is a powerful synthetic tool for natural product and drug synthesis.

Graphical abstract: Stereoselective palladium-catalyzed allylic alkylations of peptide amide enolates

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Article information

DOI
https://doi.org/10.1039/C0OB00628A
Article type
Paper
Submitted
26 Aug 2010
Accepted
14 Oct 2010
First published
01 Dec 2010

Org. Biomol. Chem., 2011,9, 872-880

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Stereoselective palladium-catalyzed allylic alkylations of peptide amide enolates

S. Datta and U. Kazmaier, Org. Biomol. Chem., 2011, 9, 872 DOI: 10.1039/C0OB00628A

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