Issue 7, 2011

Sugar-bearing tetraphenylethylene: novel fluorescent probe for studies of carbohydrate–protein interaction based on aggregation-induced emission

Abstract

Neutral sugar-bearing tetraphenylethenes (TPE) are designed and prepared as “turn-on” luminescent sensors for lectins and glycosidases based on aggregation-induced emission. Through aggregation derived from carbohydrate–lectin binding, multivalent mannosyl-bearing TPE shows a good selectivity and sensitivity to Con A by switching on the fluorescence of water-soluble tetraphenylethylene-based glyco-conjugates in aqueous solution. Meanwhile, cellobiosyl-bearing TPE can be used to investigate enzymatic hydrolysis based on emission enhancing by glycosidase-induced aggregation.

Graphical abstract: Sugar-bearing tetraphenylethylene: novel fluorescent probe for studies of carbohydrate–protein interaction based on aggregation-induced emission

Supplementary files

Article information

Article type
Paper
Submitted
06 Sep 2010
Accepted
15 Dec 2010
First published
16 Dec 2010

Org. Biomol. Chem., 2011,9, 2219-2226

Sugar-bearing tetraphenylethylene: novel fluorescent probe for studies of carbohydrate–protein interaction based on aggregation-induced emission

J. Wang, Q. Chen, N. Bian, F. Yang, J. Sun, A. Qi, C. Yan and B. Han, Org. Biomol. Chem., 2011, 9, 2219 DOI: 10.1039/C0OB00680G

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