Issue 4, 2011
From the journal:

Organic & Biomolecular Chemistry

Transition metal mediated construction of pyrrole ring on 2,3-dihydroquinolin-4(1H)-one: synthesis and pharmacological evaluation of novel tricyclic heteroarenes†

Mohosin Layek,ab   Appi Reddy M.,a   A. V. Dhanunjaya Rao,a   Mallika Alvala,c   M. K. Arunasree,c   Aminul Islam,a   K. Mukkanti,b   Javed Iqbal*c  and  Manojit Pal*c  

* Corresponding authors

a Custom Pharmaceutical Services, Dr Reddy's Laboratories Limited, Bollaram Road Miyapur, Hyderabad, India

b Chemistry Division, Institute of Science and Technology, Jawaharlal Nehru Technological University, Andhra Pradesh, India

c Institute of Life Sciences, University of Hyderabad Campus, Gachibowli, Andhra Pradesh, India

Abstract

A facile two-step method for the construction of fused pyrrole ring leading to 5-substituted 2,3-dihydro-1H-pyrrolo[3,2,1-ij]quinolin-1-ones via C–C followed by intramolecular C–N bond forming reaction is described. In vitro pharmacological evaluation and molecular modelling studies of some of the compounds synthesized are presented.

Graphical abstract: Transition metal mediated construction of pyrrole ring on 2,3-dihydroquinolin-4(1H)-one: synthesis and pharmacological evaluation of novel tricyclic heteroarenes

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Article information

DOI
https://doi.org/10.1039/C0OB00771D
Article type
Communication
Submitted
23 Sep 2010
Accepted
03 Dec 2010
First published
06 Dec 2010

Org. Biomol. Chem., 2011,9, 1004-1007

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Transition metal mediated construction of pyrrole ring on 2,3-dihydroquinolin-4(1H)-one: synthesis and pharmacological evaluation of novel tricyclic heteroarenes

M. Layek, A. Reddy M., A. V. Dhanunjaya Rao, M. Alvala, M. K. Arunasree, A. Islam, K. Mukkanti, J. Iqbal and M. Pal, Org. Biomol. Chem., 2011, 9, 1004 DOI: 10.1039/C0OB00771D

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