Issue 8, 2011
From the journal:

Organic & Biomolecular Chemistry

A one pot three-step process for the synthesis of an array of arylated benzimidazoribosyl nucleosides†

Jolanta Hałuszczak,a   Simon J. F. Macdonaldb  and  Marie E. Migaud*a  

* Corresponding authors

a Queen's University Belfast, School of Pharmacy, Medical Biology Centre, 97 Lisburn Road, Belfast, U.K.
E-mail: m.migaud@qub.ac.uk
Tel: +44 289097 2689

b GlaxoSmithKline, Stevenage Pharmaceuticals R&D facility, Gunnels Wood Road, Stevenage, Herts, U.K.

Abstract

A three-step one pot reaction/purification protocol was developed to facilitate rapid access to benzimidazole-based nucleosides, for which benzoylated benzimidazoribosyl nucleosides incorporating boronic esters were key reaction intermediates.

Graphical abstract: A one pot three-step process for the synthesis of an array of arylated benzimidazoribosyl nucleosides

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Article information

DOI
https://doi.org/10.1039/C0OB00866D
Article type
Paper
Submitted
12 Oct 2010
Accepted
05 Jan 2011
First published
04 Mar 2011

Org. Biomol. Chem., 2011,9, 2821-2831

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A one pot three-step process for the synthesis of an array of arylated benzimidazoribosyl nucleosides

J. Hałuszczak, S. J. F. Macdonald and M. E. Migaud, Org. Biomol. Chem., 2011, 9, 2821 DOI: 10.1039/C0OB00866D

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