Issue 3, 2011
From the journal:

Organic & Biomolecular Chemistry

Iron-mediated one-pot formal nitrocyclization onto unactivated alkenes†

Tsuyoshi Taniguchi,*a   Tatsuya Fujiia  and  Hiroyuki Ishibashia  

* Corresponding authors

a School of Pharmaceutical Sciences, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Kakuma-machi, Kanazawa, Japan
E-mail: tsuyoshi@p.kanazawa-u.ac.jp
Fax: +81-76-234-4439
Tel: +81-76-234-4439

Abstract

One-pot synthesis of heterocycles having a nitromethyl group was achieved by sequential steps that involved chloronitration of alkenes using iron(III) nitrate nonahydrate followed by elimination and intramolecular Michael addition. This reaction provides an efficient method for the synthesis of heterocycles due to the simple experimental procedure and the use of inexpensive reagents of low toxicity.

Graphical abstract: Iron-mediated one-pot formal nitrocyclization onto unactivated alkenes

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Article information

DOI
https://doi.org/10.1039/C0OB00905A
Article type
Communication
Submitted
20 Oct 2010
Accepted
04 Nov 2010
First published
18 Nov 2010

Org. Biomol. Chem., 2011,9, 653-655

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Iron-mediated one-pot formal nitrocyclization onto unactivated alkenes

T. Taniguchi, T. Fujii and H. Ishibashi, Org. Biomol. Chem., 2011, 9, 653 DOI: 10.1039/C0OB00905A

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