Issue 10, 2011
From the journal:

Organic & Biomolecular Chemistry

Facile synthesis of spiroisoquinolines based on photocycloaddition of isoquinoline-1,3,4-trione with oxazoles†

Chengmei Huang,a   Haitao Yu,a   Zhengrui Miao,a   Jie Zhou,a   Shuai Wang,a   Hoong-Kun Fun,b   Jianhua Xua  and  Yan Zhang*a  

* Corresponding authors

a School of Chemistry and Chemical Engineering, Key Lab of Analytical Chemistry for Life Science, Ministry of Education of China, Nanjing University, Nanjing, P. R. China
E-mail: njuzy@nju.edu.cn
Fax: +(86)-25-83685976
Tel: +(86)-25-83593072

b X-Ray Crystallography Unit, School of Physics, Universiti Sains Malaysia, 11800 USM Penang, Malaysia

Abstract

Photocycloaddition of isoquinoline-1,3,4-trione and 5-methoxyoxazoles affords spiroisoquinolineoxetanes with high regio- and diastereoselectivity. The spiroisoquinolineoxetanes can be conveniently converted into novel spiroisoquinolineoxazoline derivatives through acid catalyzed sequential reactions.

Graphical abstract: Facile synthesis of spiroisoquinolines based on photocycloaddition of isoquinoline-1,3,4-trione with oxazoles

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Article information

DOI
https://doi.org/10.1039/C1OB05143A
Article type
Communication
Submitted
27 Jan 2011
Accepted
23 Mar 2011
First published
23 Mar 2011

Org. Biomol. Chem., 2011,9, 3629-3631

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Facile synthesis of spiroisoquinolines based on photocycloaddition of isoquinoline-1,3,4-trione with oxazoles

C. Huang, H. Yu, Z. Miao, J. Zhou, S. Wang, H. Fun, J. Xu and Y. Zhang, Org. Biomol. Chem., 2011, 9, 3629 DOI: 10.1039/C1OB05143A

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