Issue 19, 2011
From the journal:

Organic & Biomolecular Chemistry

Base-free two-step synthesis of 1,3-diketones and β-ketoesters from α-diazocarbonyl compounds, trialkylboranes, and aromatic aldehydes†‡

Miguel A. Sanchez-Carmona,a   David A. Contreras-Cruza  and  Luis D. Miranda*a  

* Corresponding authors

a Instituto de Química, Universidad Nacional Autónoma de México, Circuito Exterior, Ciudad Universitaria, Coyoacán México, México
E-mail: lmiranda@servidor.unam.mx
Tel: +52 5556224440

Abstract

We describe a convergent, base-free two-step synthesis of 1,3-diketones and β-ketoesters from α-diazocarbonyl compounds, trialkylboranes, and aromatic aldehydes in a three-component process. The synthetic potential of this protocol was underscored by the synthesis of several symmetrical 1,3,5-triaryl-4-alkyl and 1,3,4,5-tetraryl substituted pyrazoles in a three-step sequence.

Graphical abstract: Base-free two-step synthesis of 1,3-diketones and β-ketoesters from α-diazocarbonyl compounds, trialkylboranes, and aromatic aldehydes

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Article information

DOI
https://doi.org/10.1039/C1OB05150D
Article type
Communication
Submitted
27 Jan 2011
Accepted
29 Jul 2011
First published
29 Jul 2011

Org. Biomol. Chem., 2011,9, 6506-6508

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Base-free two-step synthesis of 1,3-diketones and β-ketoesters from α-diazocarbonyl compounds, trialkylboranes, and aromatic aldehydes

M. A. Sanchez-Carmona, D. A. Contreras-Cruz and L. D. Miranda, Org. Biomol. Chem., 2011, 9, 6506 DOI: 10.1039/C1OB05150D

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