The switch-on luminescence sensing of histidine-rich proteins in solution: a further application of a Cu2+ ligand

Bin Wang; Yang Gao; Hong-Wei Li; Zhi-Peng Hu; Yuqing Wu

doi:10.1039/C1OB05372H

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The switch-on luminescence sensing of histidine-rich proteins in solution: a further application of a Cu²⁺ ligand†

Bin Wang,^a Yang Gao,^a Hong-Wei Li,^a Zhi-Peng Hu^a and Yuqing Wu*^a

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* Corresponding authors

^a State Key Laboratory of Supramolecular Structure and Materials, Jilin University, No. 2699, Qianjin Street, Changchun, China
E-mail: yqwu@jlu.edu.cn
Fax: +86-431-85193421
Tel: +86-431-85168730

Abstract

A new probe/Cu²⁺ complex for the detection of his-tagged protein has been developed, based on an improved probe, Dansyl-Gly-Py (1), by closely mimicing the structure of a peptide, ATCUN. In aqueous solution, 1/Cu²⁺ has good selectivity to histidine and cysteine, and further can detect histidine-rich protein by releasing the quenched fluorescence of 1.

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Article information

DOI: https://doi.org/10.1039/C1OB05372H
Article type: Communication
Submitted: 10 Mar 2011
Accepted: 12 Apr 2011
First published: 12 Apr 2011

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Org. Biomol. Chem., 2011,9, 4032-4034

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The switch-on luminescence sensing of histidine-rich proteins in solution: a further application of a Cu²⁺ ligand

B. Wang, Y. Gao, H. Li, Z. Hu and Y. Wu, Org. Biomol. Chem., 2011, 9, 4032 DOI: 10.1039/C1OB05372H

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Organic & Biomolecular Chemistry