Issue 11, 2011
From the journal:

Organic & Biomolecular Chemistry

Gold-catalysed synthesis of amino acid-derived 2,5-disubstituted oxazoles†

Christopher L. Paradise,a   Pooja R. Sarkar,a   Mina Razzaka  and  Jef K. De Brabander*a  

* Corresponding authors

a Department of Biochemistry and Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center at Dallas, 5323, Harry Hines Blvd., Dallas
E-mail: jef.debrabander@utsouthwestern.edu
Fax: +1214 648 7808
Tel: +1214 648 0320

Abstract

Amino acid-derived propargylic amides are cyclised in a one-pot, Au(III)-catalysed operation to yield 5-bromomethyl oxazoles. These compounds are further elaborated to bis-heterocycles, dipeptide mimics and more.

Graphical abstract: Gold-catalysed synthesis of amino acid-derived 2,5-disubstituted oxazoles

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Article information

DOI
https://doi.org/10.1039/C1OB05390F
Article type
Communication
Submitted
12 Mar 2011
Accepted
04 Apr 2011
First published
04 Apr 2011

Org. Biomol. Chem., 2011,9, 4017-4020

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Gold-catalysed synthesis of amino acid-derived 2,5-disubstituted oxazoles

C. L. Paradise, P. R. Sarkar, M. Razzak and J. K. De Brabander, Org. Biomol. Chem., 2011, 9, 4017 DOI: 10.1039/C1OB05390F

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