Issue 16, 2011
From the journal:

Organic & Biomolecular Chemistry

Microwave-assisted synthesis of dinucleoside analogues containing a thiazolidin-4-one linkage via one-pot tandem Staudinger/aza-Wittig/cyclization†

Fengjuan Shen,ab   Xiaoliu Li,*a   Xiaoyuan Zhang,a   Qingmei Yin,a   Zhanbin Qin,a   Hua Chen,a   Jinchao Zhanga  and  Zhaipu Mac  

* Corresponding authors

a Key Laboratory of Chemical Biology of Hebei Province, College of Chemistry and Environmental Science, Hebei University, Baoding, Hebei, China
E-mail: lixl@hbu.edu.cn
Fax: 86 0312 5971116
Tel: 86 0312 5971116

b College of Science, Hebei University of Science & Technology, Shijiazhuang, Hebei, China
E-mail: shenfjliu@126.com

c College of Life Sciences, Hebei University, Baoding, Hebei, China

Abstract

Dinucleosides containing a thiazolidin-4-one linkage were prepared by one-pot tandem Staudinger/aza-Wittig/intermolecular cyclization under microwave irradiation and their structures were confirmed. Preliminary examination of HIV-RT inhibition showed that the dinucleosides containing (R)-thiazolidin-4-one linkage are significantly more active than those containing (S)-thiazolidin-4-one linkage.

Graphical abstract: Microwave-assisted synthesis of dinucleoside analogues containing a thiazolidin-4-one linkage via one-pot tandem Staudinger/aza-Wittig/cyclization

About
Cited by
Related
Download options Please wait...

Supplementary files

Article information

DOI
https://doi.org/10.1039/C1OB05675A
Article type
Paper
Submitted
29 Apr 2011
Accepted
16 May 2011
First published
17 May 2011

Org. Biomol. Chem., 2011,9, 5766-5772

Permissions

Request permissions

Microwave-assisted synthesis of dinucleoside analogues containing a thiazolidin-4-one linkage via one-pot tandem Staudinger/aza-Wittig/cyclization

F. Shen, X. Li, X. Zhang, Q. Yin, Z. Qin, H. Chen, J. Zhang and Z. Ma, Org. Biomol. Chem., 2011, 9, 5766 DOI: 10.1039/C1OB05675A

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements