Issue 20, 2011
From the journal:

Organic & Biomolecular Chemistry

Highly effective copper-catalyzed decarboxylative coupling of aryl halides with alkynyl carboxylic acids†

Xiaoming Qu,a   Tingyi Li,a   Peng Sun,a   Yan Zhu,a   Hailong Yanga  and  Jincheng Mao*a  

* Corresponding authors

a Key Laboratory of Organic Synthesis of Jiangsu Province, College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Suzhou, P. R. China
E-mail: jcmao@suda.edu.cn

Abstract

We have developed a highly effective copper-catalyzed decarboxylative coupling of alkynylcarboxylic acids with various aryl and alkyl halides at 2 mol% loading of copper. This method is simple, economical and practical for the synthesis of disubstituted alkyne compounds.

Graphical abstract: Highly effective copper-catalyzed decarboxylative coupling of aryl halides with alkynyl carboxylic acids

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Article information

DOI
https://doi.org/10.1039/C1OB05969F
Article type
Communication
Submitted
16 Jun 2011
Accepted
24 Aug 2011
First published
25 Aug 2011

Org. Biomol. Chem., 2011,9, 6938-6942

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Highly effective copper-catalyzed decarboxylative coupling of aryl halides with alkynyl carboxylic acids

X. Qu, T. Li, P. Sun, Y. Zhu, H. Yang and J. Mao, Org. Biomol. Chem., 2011, 9, 6938 DOI: 10.1039/C1OB05969F

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