Rapid synthesis of nucleotide pyrophosphate linkages in a ball mill†
Abstract
Using a ball mill, rapid, atom-economic coupling between adenosine-5′-phosphoromorpholidate and phosphorylated ribose derivatives as their sodium or
* Corresponding authors
a
School of Chemistry and Chemical Engineering, Queen's University Belfast, David Keir Building, Stranmillis Road, Belfast, Northern Ireland, UK
E-mail:
j.vyle@qub.ac.uk
Tel: (+)44 (0) 28 9097 5485
b
School of Pharmacy, Queen's University of Belfast, Medical Biology Centre, 97 Lisburn Road, Belfast, Northern Ireland, UK
E-mail:
m.migaud@qub.ac.uk
Tel: +44 (0)28 90972689
Using a ball mill, rapid, atom-economic coupling between adenosine-5′-phosphoromorpholidate and phosphorylated ribose derivatives as their sodium or
F. Ravalico, I. Messina, M. V. Berberian, S. L. James, M. E. Migaud and J. S. Vyle, Org. Biomol. Chem., 2011, 9, 6496 DOI: 10.1039/C1OB06041D
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