Issue 23, 2011
From the journal:

Organic & Biomolecular Chemistry

Organocatalytic asymmetric Michael-type reaction between β,γ-unsaturated α-keto ester and α-nitro ketone†

Pengfei Li,ab   Sau Hing Chan,b   Albert S. C. Chan*a  and  Fuk Yee Kwong*b  

* Corresponding authors

a Department of Chemistry, Faculty of Science, Hong Kong Baptist University, Hong Kong, China
E-mail: ascchan@hkbu.edu.hk

b State Key Laboratory for Chirosciences and Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Hong Kong, China
E-mail: bcfyk@inet.polyu.edu.hk
Fax: (+852)-2364-9932
Tel: (+852)-3400-8682

Abstract

A Michael-type reaction of β,γ-unsaturated α-keto ester and α-nitro ketone was established. With a thiourea catalyst derived from cinchona alkaloid, the reactions afford products in 47–94% yields with 68–96% ee.

Graphical abstract: Organocatalytic asymmetric Michael-type reaction between β,γ-unsaturated α-keto ester and α-nitro ketone

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Article information

DOI
https://doi.org/10.1039/C1OB06191G
Article type
Communication
Submitted
18 Jul 2011
Accepted
15 Sep 2011
First published
16 Sep 2011

Org. Biomol. Chem., 2011,9, 7997-7999

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Organocatalytic asymmetric Michael-type reaction between β,γ-unsaturated α-keto ester and α-nitro ketone

P. Li, S. H. Chan, A. S. C. Chan and F. Y. Kwong, Org. Biomol. Chem., 2011, 9, 7997 DOI: 10.1039/C1OB06191G

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