Issue 23, 2011
From the journal:

Organic & Biomolecular Chemistry

Enantioselective synthesis of α-deuterium labelled chiral α-amino acids via dynamic kinetic resolution of racemic azlactones†

Joong-Suk Oh,a   Kyung Il Kimb  and  Choong Eui Song*a  

* Corresponding authors

a Department of Chemistry, Department of Energy Science, Sungkyunkwan University, 300 Cheoncheon, Jangan, Suwon, Gyeonggi, Korea
E-mail: s1673@skku.edu
Fax: (+82) 31-290-7075

b Well E&C 912, Suwon Chumdan Venture Valley Gosaek, Gwonseon, Suwon, Gyeonggi, Korea

Abstract

Catalytic dynamic kinetic resolution (DKR) of racemic azlactones with EtOD using squaramide-based dimeric cinchona alkaloid organocatalysts is shown to be a highly effective strategy for the preparation of enantiomerically pure α-deuterated chiral α-amino acids.

Graphical abstract: Enantioselective synthesis of α-deuterium labelled chiral α-amino acids via dynamic kinetic resolution of racemic azlactones

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Article information

DOI
https://doi.org/10.1039/C1OB06319G
Article type
Communication
Submitted
03 Aug 2011
Accepted
12 Sep 2011
First published
26 Sep 2011

Org. Biomol. Chem., 2011,9, 7983-7985

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Enantioselective synthesis of α-deuterium labelled chiral α-amino acids via dynamic kinetic resolution of racemic azlactones

J. Oh, K. I. Kim and C. E. Song, Org. Biomol. Chem., 2011, 9, 7983 DOI: 10.1039/C1OB06319G

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