Issue 23, 2011
From the journal:

Organic & Biomolecular Chemistry

Palladium-catalyzed carbonylative coupling of benzyl chlorides with terminal alkynes to give 1,4-diaryl-3-butyn-2-ones and related furanones†

Xiao-Feng Wu,a   Helfried Neumanna  and  Matthias Beller*a  

* Corresponding authors

a Leibniz-Institut für Katalyse e.V. an der Universitüt Rostock, Albert-Einstein-Strasse 29a, Germany
E-mail: matthias.beller@catalysis.de
Fax: (+49)381-1281-5000

Abstract

A general palladium-catalyzed carbonylative Sonogashira coupling of benzyl chlorides with terminal acetylenes has been established. Depending on the alkyne 1,4-diaryl-3-butyn-2-ones or substituted furanones are obtained in moderate to good yields. Best catalytic performance is achieved applying a mixed Pd(PPh3)Cl2/P(OPh)3 catalyst system.

Graphical abstract: Palladium-catalyzed carbonylative coupling of benzyl chlorides with terminal alkynes to give 1,4-diaryl-3-butyn-2-ones and related furanones

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Article information

DOI
https://doi.org/10.1039/C1OB06345F
Article type
Communication
Submitted
08 Aug 2011
Accepted
05 Sep 2011
First published
06 Sep 2011

Org. Biomol. Chem., 2011,9, 8003-8005

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Palladium-catalyzed carbonylative coupling of benzyl chlorides with terminal alkynes to give 1,4-diaryl-3-butyn-2-ones and related furanones

X. Wu, H. Neumann and M. Beller, Org. Biomol. Chem., 2011, 9, 8003 DOI: 10.1039/C1OB06345F

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